The lecture Immunology in the 5th semester offers a comprehensive overview of the current state of knowledge in immunological research and also includes important veterinary questions.

Hemolysis test to prove blood group tolerance. Photo: Christoph Baums

Content and Objectives of the Lecture Immunology

In the 28-hour lecture Immunology important aspects of innate and acquired immunity are explained. It includes the following aspects:

  • Innate Immunity
  • Adaptive humoral immunity
  • Adaptive cellular immunity
  • Immune response against bacteria and viruses
  • Immunotolerance using BVD MD as an example
  • Immunity against fungi and tumors
  • immunodeficiencies
  • Leishmaniasis Th1 vs Th2
  • Regulatory T cells and autoimmunity
  • Immunity in the nervous system
  • Type I and IV Hypersensitivity
  • Type II and III Hypersensitivity
  • Immunological Therapies
  • Virus evasion and defence against mycobacteria (tuberculosis)

After visiting the lecture you can

  • reflect humoral and cellular components of the immune system and assign them to the innate / adaptive or humoral / cellular immune response
  • Describe the importance of acute-phase proteins as diagnostic markers; identify the consequences of opsonisation and complement activation (phagocytosis, lysis)
  • Describe the activation of immune cells by pattern recognition receptors; reflect defensive mechanisms of the cellular innate immune response (NK cell activation, neutrophil extracellular traps)
  • Reproduce definition of blood group; explain test systems for blood group compatibility; describe the development of neonatal isoerythrolysis in horses
  • To describe the selection processes of T-/B-cells in the primary lymphatic organs
  • Explain the activation of T/B cells in the secondary lymphatic organs. To describe the circulation of immune cells in the body
  • Explain the modes of action of innate immunity (complement, phagocytosis, left shift, antigen presentation, chemotaxis)
  • Describe the activation of T cells by APC after contact with the pathogen
  • Represent the structure and of antibodies and antibody-mediated mechanisms (opsonization, complement activation, neutralization, ADCC)
  • The antibody isotypes are called
  • Explain the origin of antibody diversity as well as mechanisms of clonal selection, affinity maturation and class change
  • To demonstrate the importance of immunological memory for vaccination success
  • describe the basics of the immune system: cells and organs, innate and acquired immunity, humoral and cellular immunity, systemic and mucosal immunity, primary and secondary immune reactions
  • explain the mechanisms of host-pathogen interaction/infection immunology pathogen recognition and defence, pathogen-dependent defence (viruses, bacteria, protozoa, metazoans), extra- and intracellular infectious agents, evasion mechanisms of infectious agents, differentiation between infection and disease
  • To answer diagnostic and therapeutic relevant questions of clinical immunology/immunopathogenesis and to build up differential diagnoses and therapeutic procedures based on this (e.g. anti-inflammatory or immunosuppressive therapeutic procedures: systemic and local immunopathological manifestations in the digestive tract, locomotor system, respiratory tract, nervous system, skin (chronic inflammatory disease processes, autoimmunity, allergy, immune defects, immune tolerance, hypersensitivity reactions)
  • describe the basics of immunodiagnostics (serological procedures, cellular tests) and derive interpretation of results for the animal owner, as well as the resulting treatment procedures for individual animals or herds
  • Identify and justify current vaccination procedures, vaccine components, vaccination calendar, vaccination guidelines
  • In addition, the students should be able to use this knowledge to competently advise the animal owner during the vaccination interview

Passing the examination in Immunology is a prerequisite for admission to the examinations in Bacteriology/Mycology, Parasitology and Virology.

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