Die Forschungsergebnisse der von Mitarbeiterinnen und Mitarbeitern bearbeiteten Projekte werden in internationalen peer-review Journalen veröffentlicht und in der Forschungsgemeinschaft beachtet und zitiert.

Foto: Christian Hüller

Publikationen des Instituts für Immunologie

In den nachfolgenden Listen finden Sie, nach Jahreszahlen sortiert, die Publikationen, an denen Mitarbeiterinnen und Mitarbeiter des Instituts für Immunologie mitgearbeitet haben

  • Rungelrath, V., Öhlmann, S., Alber, G., Schrödl, W., von Köckritz-Blickwede, M., de Buhr, N., Martens, A., Baums, C. G. & Schütze, N.
    Survival of Streptococcus suis in porcine blood is limited by the antibody- and complement- dependent oxidative burst response of granulocytes.
    Infect Immun (2019). Abstract

  • Rabiger, F. V., Rothe, K., von Buttlar, H., Bismarck, D., Büttner, M., Moore, P. F., Eschke, M. & Alber, G.
    Distinct Features of Canine Non-conventional CD4-CD8α- Double-Negative TCRαβ+ vs. TCRγδ+ T Cells.
    Front Immunol 10, 2748 (2019). Abstract

  • Rieckmann, K., Seydel, A., Klose, K., Alber, G., Baums, C. G. & Schütze, N.
    Vaccination with the immunoglobulin M-degrading enzyme of Streptococcus suis, Ide Ssuis, leads to protection against a highly virulent serotype 9 strain.
    Vaccine X 3, 100046 (2019). Abstract

  • Schneider, L. E., Protschka, M., Müller, U., Muhsen, M., Magin, T. M., Anderegg, U., Saalbach, A., Büttner, M., Alber, G. & Siegemund, S.
    Orf virus infection of human keratinocytes and dermal fibroblasts: Limited virus detection and interference with intercellular adhesion molecule-1 up-regulation.
    Exp Dermatol 28, 142–151 (2019). Abstract
  • Rabiger, F. V., Bismarck, D., Protschka, M., Köhler, G., Moore, P. F., Büttner, M., Buttlar, H. von, Alber, G. & Eschke, M.
    Canine tissue-associated CD4+CD8α+ double-positive T cells are an activated T cell subpopulation with heterogeneous functional potential.
    PLoS ONE 14, e0213597 (2019). Abstract
  • Muhsen, M., Protschka, M., Schneider, L. E., Müller, U., Köhler, G., Magin, T. M., Büttner, M., Alber, G. & Siegemund, S.
    Orf virus (ORFV) infection in a three-dimensional human skin model: Characteristic cellular alterations and interference with keratinocyte differentiation.
    PLoS ONE 14, e0210504 (2019). Abstract
  • Fornefett, J., Krause, J., Klose, K., Fingas, F., Hassert, R., Benga, L., Grunwald, T., Müller, U., Schrödl, W. & Baums, C. G.
    Comparative analysis of humoral immune responses and pathologies of BALB/c and C57BL/6 wildtype mice experimentally infected with a highly virulent Rodentibacter pneumotropicus (Pasteurella pneumotropica) strain.
    BMC Microbiol 18, 45 (2018). Abstract
  • Fornefett, J., Krause, J., Klose, K., Fingas, F., Hassert, R., Eisenberg, T., Schrödl, W., Grunwald, T., Müller, U. & Baums, C. G.
    Comparative analysis of clinics, pathologies and immune responses in BALB/c and C57BL/6 mice infected with Streptobacillus moniliformis.
    Microbes Infect 20, 101–110 (2018). Abstract
  • Ayrle, H., Mevissen, M., Kaske, M., Vögtlin, A., Fricker, R., Hoffmann, B., Büttner, M., Marinovic, Z. & Walkenhorst, M.
    Colostral transmission of BTV-8 antibodies from dairy cows six years after vaccination.
    Vaccine 36, 5807–5810 (2018). Abstract
  • Schanzenbach, C. I., Bernal-Ulloa, S. M., van der Weijden, V. A., Pfaffl, M. W., Büttner, M., Wünsch, A. & Ulbrich, S. E.
    Blastocysts depict sex-specific signalling of IFNT transcription, translation and activity.
    Reproduction (2018). Abstract
  • Müller, U., Schaub, G. A., Mossmann, H., Köhler, G., Carsetti, R. & Hölscher, C.
    Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection.
    Front Immunol 9, 2794 (2018). Abstract
  • Rungelrath, V., Weiße, C., Schütze, N., Müller, U., Meurer, M., Rohde, M., Seele, J., Valentin-Weigand, P., Kirschfink, M., Beineke, A., Schrödl, W., Bergmann, R. & Baums, C. G.
    IgM cleavage by Streptococcus suis reduces IgM bound to the bacterial surface and is a novel complement evasion mechanism.
    Virulence 9, 1314–1337 (2018). Abstract
  • Firacative, C., Gressler, A. E., Schubert, K., Schulze, B., Müller, U., Brombacher, F., Bergen, M. von & Alber, G.
    Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection.
    Sci Rep 8, 2681 (2018). Abstract
  • Rothe, K., Bismarck, D., Büttner, M., Alber, G. & Buttlar, H. von.
    Canine peripheral blood CD4+CD8+ double-positive T cell subpopulations exhibit distinct T cell phenotypes and effector functions.
    Vet Immunol Immunopathol 185, 48–56 (2017).
  • Ebner, F., Schwiertz, P., Steinfelder, S., Pieper, R., Zentek, J., Schütze, N., Baums, C. G., Alber, G., Geldhof, P. & Hartmann, S.
    Pathogen-Reactive T Helper Cell Analysis in the Pig.
    Front Immunol 8, 565 (2017).
  • Delling, C., Lendner, M., Müller, U. & Daugschies, A.
    Improvement of in vitro evaluation of chemical disinfectants for efficacy on Cryptosporidium parvum oocysts.
    Vet Parasitol 245, 5–13 (2017).
  • Piehler, D., Eschke, M., Schulze, B., Protschka, M., Müller, U., Grahnert, A., Richter, T., Heyen, L., Köhler, G., Brombacher, F. & Alber, G.
    The IL-33 receptor (ST2) regulates early IL-13 production in fungus-induced allergic airway inflammation.
    Mucosal Immunol 9, 937–949 (2016).
  • Heyen, L., Müller, U., Siegemund, S., Schulze, B., Protschka, M., Alber, G. & Piehler, D.
    Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis.
    Pathog Dis 74 (2016).
  • Schulze, B., Piehler, D., Eschke, M., Heyen, L., Protschka, M., Köhler, G. & Alber, G.
    Therapeutic expansion of CD4+FoxP3+ regulatory T cells limits allergic airway inflammation during pulmonary fungal infection.
    Pathog Dis 74, ftw020 (2016).
  • Eschke, M., Piehler, D., Schulze, B., Richter, T., Grahnert, A., Protschka, M., Müller, U., Köhler, G., Höfling, C., Rossner, S. & Alber, G.
    A novel experimental model of Cryptococcus neoformans-related immune reconstitution inflammatory syndrome (IRIS) provides insights into pathogenesis.
    Eur J Immunol 45, 3339–3350 (2015).
  • Grahnert, A., Müller, U., Buttlar, H. von, Treudler, R. & Alber, G.
    Analysis of asthma patients for cryptococcal seroreactivity in an urban German area.
    Med Mycol 53, 576–586 (2015).
  • Buttlar, H. von, Bismarck, D. & Alber, G.
    Peripheral canine CD4(+)CD8(+) double-positive T cells - unique amongst others.
    Vet Immunol Immunopathol 168, 169–175 (2015).
  • Bismarck, D., Moore, P. F., Alber, G. & Buttlar, H. von.
    Canine CD4(+)CD8(+) double-positive T cells can develop from CD4(+) and CD8(+) T cells.
    Vet Immunol Immunopathol 162, 72–82 (2014).
  • Grahnert, A., Richter, T., Piehler, D., Eschke, M., Schulze, B., Müller, U., Protschka, M., Köhler, G., Sabat, R., Brombacher, F. & Alber, G.
    IL-4 receptor-alpha-dependent control of Cryptococcus neoformans in the early phase of pulmonary infection.
    PLoS ONE 9, e87341 (2014).
  • Schulze, B., Piehler, D., Eschke, M., Buttlar, H. von, Köhler, G., Sparwasser, T. & Alber, G.
    CD4(+) FoxP3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection.
    Eur J Immunol 44, 3596–3604 (2014).
  • Buttlar, H. von, Siegemund, S., Büttner, M. & Alber, G.
    Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.
    PLoS ONE 9, e106188 (2014).
  • Müller, U., Stenzel, W., Piehler, D., Grahnert, A., Protschka, M., Köhler, G., Frey, O., Held, J., Richter, T., Eschke, M., Kamradt, T., Brombacher, F. & Alber, G.
    Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response.
    Int Immunol 25, 459–470 (2013).
  • Berthold, N., Czihal, P., Fritsche, S., Sauer, U., Schiffer, G., Knappe, D., Alber, G. & Hoffmann, R.
    Novel apidaecin 1b analogs with superior serum stabilities for treatment of infections by gram-negative pathogens.
    Antimicrob Agents Chemother 57, 402–409 (2013).
  • Piehler, D., Grahnert, A., Eschke, M., Richter, T., Köhler, G., Stenzel, W. & Alber, G.
    T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis.
    Mucosal Immunol 6, 405–414 (2013).
  • Bismarck, D., Schütze, N., Moore, P., Büttner, M., Alber, G. & Buttlar, H. v.
    Canine CD4+CD8+ double positive T cells in peripheral blood have features of activated T cells.
    Vet Immunol Immunopathol 149, 157–166 (2012).
  • Knappe, D., Fritsche, S., Alber, G., Köhler, G., Hoffmann, R. & Müller, U.
    Oncocin derivative Onc72 is highly active against Escherichia coli in a systemic septicaemia infection mouse model.
    J Antimicrob Chemother 67, 2445–2451 (2012).
  • Fritsche, S., Knappe, D., Berthold, N., Buttlar, H. von, Hoffmann, R. & Alber, G.
    Absence of in vitro innate immunomodulation by insect-derived short proline-rich antimicrobial peptides points to direct antibacterial action in vivo.
    J Pept Sci 18, 599–608 (2012).
  • Müller, U., Piehler, D., Stenzel, W., Köhler, G., Frey, O., Held, J., Grahnert, A., Richter, T., Eschke, M., Kamradt, T., Brombacher, F. & Alber, G.
    Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis.
    Mucosal Immunol 5, 299–310 (2012).
  • Czihal, P., Knappe, D., Fritsche, S., Zahn, M., Berthold, N., Piantavigna, S., Müller, U., van Dorpe, S., Herth, N., Binas, A., Köhler, G., Spiegeleer, B. de, Martin, L. L., Nolte, O., Sträter, N., Alber, G. & Hoffmann, R.
    Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens.
    ACS Chem Biol 7, 1281–1291 (2012).
  • Schumann, J., Muller, U. & Blessing, M.
    TGF-β signaling in T cells is not essential for Th17 cell development in the mouse.
    J Biol Regul Homeost Agents 26, 357–366 (2012).
  • Piehler, D., Stenzel, W., Grahnert, A., Held, J., Richter, L., Köhler, G., Richter, T., Eschke, M., Alber, G. & Müller, U.
    Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis.
    Am J Pathol 179, 733–744 (2011).
  • Koethe, M., Pott, S., Ludewig, M., Bangoura, B., Zöller, B., Daugschies, A., Tenter, A. M., Spekker, K., Bittame, A., Mercier, C., Fehlhaber, K. & Straubinger, R. K.
    Prevalence of specific IgG-antibodies against Toxoplasma gondii in domestic turkeys determined by kinetic ELISA based on recombinant GRA7 and GRA8.
    Vet Parasitol 180, 179–190 (2011).
  • Liebold, T., Straubinger, R. K. & Rauwald, H. W.
    Growth inhibiting activity of lipophilic extracts from Dipsacus sylvestris Huds. roots against Borrelia burgdorferi s. s. in vitro.
    Pharmazie 66, 628–630 (2011).
  • Liebscher, I., Müller, U., Teupser, D., Engemaier, E., Engel, K. M. Y., Ritscher, L., Thor, D., Sangkuhl, K., Ricken, A., Wurm, A., Piehler, D., Schmutzler, S., Fuhrmann, H., Albert, F. W., Reichenbach, A., Thiery, J., Schöneberg, T. & Schulz, A.
    Altered immune response in mice deficient for the G protein-coupled receptor GPR34.
    J Biol Chem 286, 2101–2110 (2011).
  • Breuer, J., Müller, U., Locher, L., Spallek, A., Recknagel, S., Uhlig, A. & Schusser, G. F.
    Differentiation of viable, apoptotic and necrotic cells in bronchoalveolar lavage fluid of normal horses and horses with recurrent airway obstruction.
    Berl Munch Tierarztl Wochenschr 124, 154–160 (2011).
  • Khalafalla, R. E., Müller, U., Shahiduzzaman, M., Dyachenko, V., Desouky, A. Y., Alber, G. & Daugschies, A.
    Effects of curcumin (diferuloylmethane) on Eimeria tenella sporozoites in vitro.
    Parasitol Res 108, 879–886 (2011).
  • Knauer, J., Krupka, I., Fueldner, C., Lehmann, J. & Straubinger, R. K.
    Evaluation of the preventive capacities of a topically applied azithromycin formulation against Lyme borreliosis in a murine model.
    J Antimicrob Chemother 66, 2814–2822 (2011).
  • Al-Robaiy, S., Dihazi, H., Kacza, J., Seeger, J., Schiller, J., Huster, D., Knauer, J. & Straubinger, R. K.
    Metamorphosis of Borrelia burgdorferi organisms--RNA, lipid and protein composition in context with the spirochetes' shape.
    J Basic Microbiol 50 Suppl 1, S5-17 (2010).
  • Kleinschek, M. A., Müller, U., Schütze, N., Sabat, R., Straubinger, R. K., Blumenschein, W. M., McClanahan, T., Kastelein, R. A. & Alber, G.
    Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection.
    Int Immunol 22, 81–90 (2010).
  • Hutschenreuther, A., Birkemeyer, C., Grötzinger, K., Straubinger, R. K. & Rauwald, H. W.
    Growth inhibiting activity of volatile oil from Cistus creticus L. against Borrelia burgdorferi s.s. in vitro.
    Pharmazie 65, 290–295 (2010).
  • Schütze, N., Raue, R., Büttner, M., Köhler, G., McInnes, C. J. & Alber, G.
    Specific antibodies induced by inactivated parapoxvirus ovis potently enhance oxidative burst in canine blood polymorphonuclear leukocytes and monocytes.
    Vet Microbiol 140, 81–91 (2010).
  • Schütze, N., Raue, R., Büttner, M. & Alber, G.
    Inactivated parapoxvirus ovis activates canine blood phagocytes and T lymphocytes.
    Vet Microbiol 137, 260–267 (2009).
  • Siegemund, S., Schütze, N., Schulz, S., Wolk, K., Nasilowska, K., Straubinger, R. K., Sabat, R. & Alber, G.
    Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
    Int Immunol 21, 555–565 (2009).
  • Krupka, I., Knauer, J., Lorentzen, L., O'Connor, T. P., Saucier, J. & Straubinger, R. K.
    Borrelia burgdorferi sensu lato species in Europe induce diverse immune responses against C6 peptides in infected mice.
    Clin Vaccine Immunol 16, 1546–1562 (2009).
  • Stenzel, W., Müller, U., Köhler, G., Heppner, F. L., Blessing, M., McKenzie, A. N. J., Brombacher, F. & Alber, G.
    IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis.
    Am J Pathol 174, 486–496 (2009).
  • Siegemund, S., Hartl, A., Buttlar, H. von, Dautel, F., Raue, R., Freudenberg, M. A., Fejer, G., Büttner, M., Köhler, G., Kirschning, C. J., Sparwasser, T. & Alber, G.
    Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis.
    J Virol 83, 9411–9422 (2009).
  • Siegemund, S. & Alber, G.
    Cryptococcus neoformans activates bone marrow-derived conventional dendritic cells rather than plasmacytoid dendritic cells and down-regulates macrophages.
    FEMS Immunol Med Microbiol 52, 417–427 (2008).
  • Schulz, S. M., Köhler, G., Holscher, C., Iwakura, Y. & Alber, G.
    IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance.
    Int Immunol 20, 1129–1138 (2008).
  • Müller, U., Vogel, P., Alber, G. & Schaub, G. A.
    The innate immune system of mammals and insects.
    Contrib Microbiol 15, 21–44 (2008).
  • Schulz, S. M., Köhler, G., Schütze, N., Knauer, J., Straubinger, R. K., Chackerian, A. A., Witte, E., Wolk, K., Sabat, R., Iwakura, Y., Holscher, C., Müller, U., Kastelein, R. A. & Alber, G.
    Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17.
    J Immunol 181, 7891–7901 (2008).
  • Müller, U., Stenzel, W., Köhler, G., Polte, T., Blessing, M., Mann, A., Piehler, D., Brombacher, F. & Alber, G.
    A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis.
    J Infect Dis 198, 1714–1721 (2008).
  • Töpfer, K. H. & Straubinger, R. K.
    Characterization of the humoral immune response in dogs after vaccination against the Lyme borreliosis agent A study with five commercial vaccines using two different vaccination schedules.
    Vaccine 25, 314–326 (2007).
  • Müller, U., Stenzel, W., Köhler, G., Werner, C., Polte, T., Hansen, G., Schütze, N., Straubinger, R. K., Blessing, M., McKenzie, A. N. J., Brombacher, F. & Alber, G.
    IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans.
    J Immunol 179, 5367–5377 (2007).
  • Knauer, J., Siegemund, S., Müller, U., Al-Robaiy, S., Kastelein, R. A., Alber, G. & Straubinger, R. K.
    Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells.
    FEMS Immunol Med Microbiol 49, 353–363 (2007).
  • Siegemund, S., Schütze, N., Freudenberg, M. A., Lutz, M. B., Straubinger, R. K. & Alber, G.
    Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis.
    Immunobiology 212, 739–750 (2007).
  • Alber, G., Al-Robaiy, S., Kleinschek, M., Knauer, J., Krumbholz, P., Richter, J., Schoeneberger, S., Schuetze, N., Schulz, S., Toepfer, K., Voigtlaender, R., Lehmann, J. & Mueller, U.
    Induction of immunity and inflammation by interleukin-12 family members.
    Ernst Schering Res Found Workshop, 107–127 (2006).
  • Kleinschek, M. A., Muller, U., Brodie, S. J., Stenzel, W., Kohler, G., Blumenschein, W. M., Straubinger, R. K., McClanahan, T., Kastelein, R. A. & Alber, G.
    IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12.
    J Immunol 176, 1098–1106 (2006).
  • Lehmann, J., Springer, S., Werner, C. E., Lindner, T., Bellmann, S., Straubinger, R. K., Selbitz, H.-J. & Alber, G.
    Immunity induced with a Salmonella enterica serovar Enteritidis live vaccine is regulated by Th1-cell-dependent cellular and humoral effector mechanisms in susceptible BALB/c mice.
    Vaccine 24, 4779–4793 (2006).
  • Al-Robaiy, S., Knauer, J. & Straubinger, R. K.
    Borrelia burgdorferi organisms lacking plasmids 25 and 28-1 are internalized by human blood phagocytes at a rate identical to that of the wild-type strain.
    Infect Immun 73, 5547–5553 (2005).
  • Schuetze, N., Schoeneberger, S., Mueller, U., Freudenberg, M. A., Alber, G. & Straubinger, R. K.
    IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages.
    Int Immunol 17, 649–659 (2005).
  • Müller, U., Sobek, V., Balkow, S., Hölscher, C., Müllbacher, A., Museteanu, C., Mossmann, H. & Simon, M. M.
    Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway.
    Eur J Immunol 33, 70–78 (2003).
  • Lehmann, J., Bellmann, S., Werner, C., Schröder, R., Schütze, N. & Alber, G.
    IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis.
    J Immunol 167, 5304–5315 (2001).
  • Straubinger, R. K., Dharma Rao, T., Davidson, E., Summers, B. A., Jacobson, R. H. & Frey, A. B.
    Protection against tick-transmitted Lyme disease in dogs vaccinated with a multiantigenic vaccine.
    Vaccine 20, 181–193 (2001).
  • Decken, K., Köhler, G., Palmer-Lehmann, K., Wunderlin, A., Mattner, F., Magram, J., Gately, M. K. & Alber, G.
    Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans.
    Infect Immun 66, 4994–5000 (1998).
  • Lehmann, J. & Alber, G.
    Murine leishmaniosis: a paradigm for the importance of T helper 1 and T helper 2 cells.
    Rev - Off Int Epizoot 17, 176–187 (1998).

Weitere Informationen finden Sie in der Forschungsdatenbank der Universität Leipzig

fob.uni-leipzig.de

Das könnte sie auch interessieren

Forschung rund ums Thema Kryptokokkose

mehr erfahren

Forschung rund ums Thema Immunsystem des Schweins

mehr erfahren

Forschung rund ums Thema T-Zellen des Hundes

mehr erfahren

Promotionenen, Habilitationen und mehr

mehr erfahren

Geräte des Instituts

mehr erfahren