The lecture Immunology in the 5th FS offers a comprehensive overview of the current state of knowledge in immunological research and also includes important veterinary questions.

Hemolysis test to prove blood group tolerance. Photo: Christoph Baums
  • Innate Immunity
  • Adaptive humoral immunity
  • Adaptive cellular immunity
  • Immune response against bacteria and viruses
  • Immunotolerance using BVD MD as an example
  • Immunity against fungi and tumors
  • immunodeficiencies
  • Leishmaniasis Th1 vs Th2
  • Regulatory T cells and autoimmunity
  • Immunity in the nervous system
  • Type I and IV Hypersensitivity
  • Type II and III Hypersensitivity
  • Immunological Therapies
  • Virus evasion and defence against mycobacteria (tuberculosis)
  • Being able to reproduce humoral and cellular components of the immune system and assign them to the congenital/adaptive or humoral/cellular immune response
  • Being able to describe the significance of acute-phase proteins as diagnostic markers; being able to identify the consequences of opsonization and complement activation (phagocytosis, lysis)
  • Being able to describe the activation of immune cells by pattern recognition receptors; being able to reproduce defense mechanisms of the cellular innate immune response (NK cell activation, neutrophil extracellular traps)
  • definition of blood group; to be able to explain test systems for blood group compatibility; to be able to describe the development of neonatal isoerythrolysis in horses;
  • Describe the selection processes of T/B cells in the primary lymphatic organs.
  • Being able to explain the activation of T/B cells in secondary lymphatic organs. Being able to describe the circulation of immune cells in the body
  • Being able to explain the modes of action of innate immunity (complement, phagocytosis, left shift, antigen presentation, chemotaxis)
  • Being able to describe the activation of T cells by APC after pathogen contact.
  • Being able to reproduce the structure and mechanisms mediated by antibodies and antibodies (opsonization, complement activation, neutralization, ADCC). Being able to name antibody isotypes.
  • Being able to explain the development of antibody diversity as well as mechanisms of clonal selection, affinity maturation and class change. Being able to explain the importance of immunological memory for vaccination success.
  • Being able to describe the basics of the immune system: Cells and organs, innate and acquired immunity, humoral and cellular immunity, systemic and mucosal immunity, primary and secondary immune responses.
  • explain the mechanisms of host-pathogen interaction/infection immunology: Pathogen recognition and defence, pathogen-dependent defence (viruses, bacteria, protozoa, metazoans), extra- and intracellular infectious agents, evasion mechanisms of infectious agents, differentiation between infection and disease.
  • To be able to answer diagnostic and therapy relevant questions of clinical immunology/immunopathogenesis and to build up differential diagnoses and therapy procedures based on them (e.g. anti-inflammatory or immunosuppressive therapy procedures: systemic and local immunopathological manifestations in the digestive tract, locomotor system, respiratory tract, nervous system, skin (chronic inflammatory disease processes, autoimmunity, allergy, immunodeficiencies, immunotolerance, hypersensitivity reactions).
  • To identify the basics of immunodiagnostics (serological methods, cellular tests) and to derive interpretations of findings for the animal owner as well as resulting treatment methods for single animals or herds of animals
  • Identify and substantiate current vaccination procedures, vaccine components, vaccination calendars, vaccination guidelines. In addition, the students should be able to give competent advice to the animal owner during the vaccination interview.

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