The research results of the projects carried out by staff members are published in international peer-review journals and are noted and quoted in the research community.

Publications of the Institute of Immunology

In the following lists, sorted by year, you will find the publications on which staff members of the Institute of Immunology have worked.

  • Schneider, L. E., Protschka, M., Müller, U., Muhsen, M., Magin, T. M., Anderegg, U., Saalbach, A., Büttner, M., Alber, G. & Siegemund, S. Orf virus infection of human keratinocytes and dermal fibroblasts: Limited virus detection and interference with intercellular adhesion molecule-1 up-regulation. Exp Dermatol 28, 142–151 (2019).
  • Rabiger, F. V., Bismarck, D., Protschka, M., Köhler, G., Moore, P. F., Büttner, M., Buttlar, H. von, Alber, G. & Eschke, M. Canine tissue-associated CD4+CD8α+ double-positive T cells are an activated T cell subpopulation with heterogeneous functional potential. PLoS ONE 14, e0213597 (2019).
  • Muhsen, M., Protschka, M., Schneider, L. E., Müller, U., Köhler, G., Magin, T. M., Büttner, M., Alber, G. & Siegemund, S. Orf virus (ORFV) infection in a three-dimensional human skin model: Characteristic cellular alterations and interference with keratinocyte differentiation. PLoS ONE 14, e0210504 (2019).
  • Fornefett, J., Krause, J., Klose, K., Fingas, F., Hassert, R., Benga, L., Grunwald, T., Müller, U., Schrödl, W. & Baums, C. G. Comparative analysis of humoral immune responses and pathologies of BALB/c and C57BL/6 wildtype mice experimentally infected with a highly virulent Rodentibacter pneumotropicus (Pasteurella pneumotropica) strain. BMC Microbiol 18, 45 (2018).
  • Fornefett, J., Krause, J., Klose, K., Fingas, F., Hassert, R., Eisenberg, T., Schrödl, W., Grunwald, T., Müller, U. & Baums, C. G. Comparative analysis of clinics, pathologies and immune responses in BALB/c and C57BL/6 mice infected with Streptobacillus moniliformis. Microbes Infect 20, 101–110 (2018).
  • Ayrle, H., Mevissen, M., Kaske, M., Vögtlin, A., Fricker, R., Hoffmann, B., Büttner, M., Marinovic, Z. & Walkenhorst, M. Colostral transmission of BTV-8 antibodies from dairy cows six years after vaccination. Vaccine 36, 5807–5810 (2018).
  • Schanzenbach, C. I., Bernal-Ulloa, S. M., van der Weijden, V. A., Pfaffl, M. W., Büttner, M., Wünsch, A. & Ulbrich, S. E. Blastocysts depict sex-specific signalling of IFNT transcription, translation and activity. Reproduction (2018).
  • Müller, U., Schaub, G. A., Mossmann, H., Köhler, G., Carsetti, R. & Hölscher, C. Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection. Front Immunol 9, 2794 (2018).
  • Rungelrath, V., Weiße, C., Schütze, N., Müller, U., Meurer, M., Rohde, M., Seele, J., Valentin-Weigand, P., Kirschfink, M., Beineke, A., Schrödl, W., Bergmann, R. & Baums, C. G. IgM cleavage by Streptococcus suis reduces IgM bound to the bacterial surface and is a novel complement evasion mechanism. Virulence 9, 1314–1337 (2018).
  • Firacative, C., Gressler, A. E., Schubert, K., Schulze, B., Müller, U., Brombacher, F., Bergen, M. von & Alber, G. Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection. Sci Rep 8, 2681 (2018).
  • Rothe, K., Bismarck, D., Büttner, M., Alber, G. & Buttlar, H. von. Canine peripheral blood CD4+CD8+ double-positive T cell subpopulations exhibit distinct T cell phenotypes and effector functions. Vet Immunol Immunopathol 185, 48–56 (2017).
  • Ebner, F., Schwiertz, P., Steinfelder, S., Pieper, R., Zentek, J., Schütze, N., Baums, C. G., Alber, G., Geldhof, P. & Hartmann, S. Pathogen-Reactive T Helper Cell Analysis in the Pig. Front Immunol 8, 565 (2017).
  • Delling, C., Lendner, M., Müller, U. & Daugschies, A. Improvement of in vitro evaluation of chemical disinfectants for efficacy on Cryptosporidium parvum oocysts. Vet Parasitol 245, 5–13 (2017).
  • Piehler, D., Eschke, M., Schulze, B., Protschka, M., Müller, U., Grahnert, A., Richter, T., Heyen, L., Köhler, G., Brombacher, F. & Alber, G. The IL-33 receptor (ST2) regulates early IL-13 production in fungus-induced allergic airway inflammation. Mucosal Immunol 9, 937–949 (2016).
  • Heyen, L., Müller, U., Siegemund, S., Schulze, B., Protschka, M., Alber, G. & Piehler, D. Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis. Pathog Dis 74 (2016).
  • Schulze, B., Piehler, D., Eschke, M., Heyen, L., Protschka, M., Köhler, G. & Alber, G. Therapeutic expansion of CD4+FoxP3+ regulatory T cells limits allergic airway inflammation during pulmonary fungal infection. Pathog Dis 74, ftw020 (2016).
  • Eschke, M., Piehler, D., Schulze, B., Richter, T., Grahnert, A., Protschka, M., Müller, U., Köhler, G., Höfling, C., Rossner, S. & Alber, G. A novel experimental model of Cryptococcus neoformans-related immune reconstitution inflammatory syndrome (IRIS) provides insights into pathogenesis. Eur J Immunol 45, 3339–3350 (2015).
  • Grahnert, A., Müller, U., Buttlar, H. von, Treudler, R. & Alber, G. Analysis of asthma patients for cryptococcal seroreactivity in an urban German area. Med Mycol 53, 576–586 (2015).
  • Buttlar, H. von, Bismarck, D. & Alber, G. Peripheral canine CD4(+)CD8(+) double-positive T cells - unique amongst others. Vet Immunol Immunopathol 168, 169–175 (2015).
  • Bismarck, D., Moore, P. F., Alber, G. & Buttlar, H. von. Canine CD4(+)CD8(+) double-positive T cells can develop from CD4(+) and CD8(+) T cells. Vet Immunol Immunopathol 162, 72–82 (2014).
  • Grahnert, A., Richter, T., Piehler, D., Eschke, M., Schulze, B., Müller, U., Protschka, M., Köhler, G., Sabat, R., Brombacher, F. & Alber, G. IL-4 receptor-alpha-dependent control of Cryptococcus neoformans in the early phase of pulmonary infection. PLoS ONE 9, e87341 (2014).
  • Schulze, B., Piehler, D., Eschke, M., Buttlar, H. von, Köhler, G., Sparwasser, T. & Alber, G. CD4(+) FoxP3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection. Eur J Immunol 44, 3596–3604 (2014).
  • Buttlar, H. von, Siegemund, S., Büttner, M. & Alber, G. Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells. PLoS ONE 9, e106188 (2014).
  • Müller, U., Stenzel, W., Piehler, D., Grahnert, A., Protschka, M., Köhler, G., Frey, O., Held, J., Richter, T., Eschke, M., Kamradt, T., Brombacher, F. & Alber, G. Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response. Int Immunol 25, 459–470 (2013).
  • Berthold, N., Czihal, P., Fritsche, S., Sauer, U., Schiffer, G., Knappe, D., Alber, G. & Hoffmann, R. Novel apidaecin 1b analogs with superior serum stabilities for treatment of infections by gram-negative pathogens. Antimicrob Agents Chemother 57, 402–409 (2013).
  • Piehler, D., Grahnert, A., Eschke, M., Richter, T., Köhler, G., Stenzel, W. & Alber, G. T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis. Mucosal Immunol 6, 405–414 (2013).
  • Bismarck, D., Schütze, N., Moore, P., Büttner, M., Alber, G. & Buttlar, H. v. Canine CD4+CD8+ double positive T cells in peripheral blood have features of activated T cells. Vet Immunol Immunopathol 149, 157–166 (2012).
  • Knappe, D., Fritsche, S., Alber, G., Köhler, G., Hoffmann, R. & Müller, U. Oncocin derivative Onc72 is highly active against Escherichia coli in a systemic septicaemia infection mouse model. J Antimicrob Chemother 67, 2445–2451 (2012).
  • Fritsche, S., Knappe, D., Berthold, N., Buttlar, H. von, Hoffmann, R. & Alber, G. Absence of in vitro innate immunomodulation by insect-derived short proline-rich antimicrobial peptides points to direct antibacterial action in vivo. J Pept Sci 18, 599–608 (2012).
  • Müller, U., Piehler, D., Stenzel, W., Köhler, G., Frey, O., Held, J., Grahnert, A., Richter, T., Eschke, M., Kamradt, T., Brombacher, F. & Alber, G. Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Mucosal Immunol 5, 299–310 (2012).
  • Czihal, P., Knappe, D., Fritsche, S., Zahn, M., Berthold, N., Piantavigna, S., Müller, U., van Dorpe, S., Herth, N., Binas, A., Köhler, G., Spiegeleer, B. de, Martin, L. L., Nolte, O., Sträter, N., Alber, G. & Hoffmann, R. Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens. ACS Chem Biol 7, 1281–1291 (2012).
  • Schumann, J., Muller, U. & Blessing, M. TGF-β signaling in T cells is not essential for Th17 cell development in the mouse. J Biol Regul Homeost Agents 26, 357–366 (2012).
  • Piehler, D., Stenzel, W., Grahnert, A., Held, J., Richter, L., Köhler, G., Richter, T., Eschke, M., Alber, G. & Müller, U. Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis. Am J Pathol 179, 733–744 (2011).
  • Koethe, M., Pott, S., Ludewig, M., Bangoura, B., Zöller, B., Daugschies, A., Tenter, A. M., Spekker, K., Bittame, A., Mercier, C., Fehlhaber, K. & Straubinger, R. K. Prevalence of specific IgG-antibodies against Toxoplasma gondii in domestic turkeys determined by kinetic ELISA based on recombinant GRA7 and GRA8. Vet Parasitol 180, 179–190 (2011).
  • Liebold, T., Straubinger, R. K. & Rauwald, H. W. Growth inhibiting activity of lipophilic extracts from Dipsacus sylvestris Huds. roots against Borrelia burgdorferi s. s. in vitro. Pharmazie 66, 628–630 (2011).
  • Liebscher, I., Müller, U., Teupser, D., Engemaier, E., Engel, K. M. Y., Ritscher, L., Thor, D., Sangkuhl, K., Ricken, A., Wurm, A., Piehler, D., Schmutzler, S., Fuhrmann, H., Albert, F. W., Reichenbach, A., Thiery, J., Schöneberg, T. & Schulz, A. Altered immune response in mice deficient for the G protein-coupled receptor GPR34. J Biol Chem 286, 2101–2110 (2011).
  • Breuer, J., Müller, U., Locher, L., Spallek, A., Recknagel, S., Uhlig, A. & Schusser, G. F. Differentiation of viable, apoptotic and necrotic cells in bronchoalveolar lavage fluid of normal horses and horses with recurrent airway obstruction. Berl Munch Tierarztl Wochenschr 124, 154–160 (2011).
  • Khalafalla, R. E., Müller, U., Shahiduzzaman, M., Dyachenko, V., Desouky, A. Y., Alber, G. & Daugschies, A. Effects of curcumin (diferuloylmethane) on Eimeria tenella sporozoites in vitro. Parasitol Res 108, 879–886 (2011).
  • Knauer, J., Krupka, I., Fueldner, C., Lehmann, J. & Straubinger, R. K. Evaluation of the preventive capacities of a topically applied azithromycin formulation against Lyme borreliosis in a murine model. J Antimicrob Chemother 66, 2814–2822 (2011).
  • Al-Robaiy, S., Dihazi, H., Kacza, J., Seeger, J., Schiller, J., Huster, D., Knauer, J. & Straubinger, R. K. Metamorphosis of Borrelia burgdorferi organisms--RNA, lipid and protein composition in context with the spirochetes' shape. J Basic Microbiol 50 Suppl 1, S5-17 (2010).
  • Kleinschek, M. A., Müller, U., Schütze, N., Sabat, R., Straubinger, R. K., Blumenschein, W. M., McClanahan, T., Kastelein, R. A. & Alber, G. Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection. Int Immunol 22, 81–90 (2010).
  • Hutschenreuther, A., Birkemeyer, C., Grötzinger, K., Straubinger, R. K. & Rauwald, H. W. Growth inhibiting activity of volatile oil from Cistus creticus L. against Borrelia burgdorferi s.s. in vitro. Pharmazie 65, 290–295 (2010).
  • Schütze, N., Raue, R., Büttner, M., Köhler, G., McInnes, C. J. & Alber, G. Specific antibodies induced by inactivated parapoxvirus ovis potently enhance oxidative burst in canine blood polymorphonuclear leukocytes and monocytes. Vet Microbiol 140, 81–91 (2010).
  • Schütze, N., Raue, R., Büttner, M. & Alber, G. Inactivated parapoxvirus ovis activates canine blood phagocytes and T lymphocytes. Vet Microbiol 137, 260–267 (2009).
  • Siegemund, S., Schütze, N., Schulz, S., Wolk, K., Nasilowska, K., Straubinger, R. K., Sabat, R. & Alber, G. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Int Immunol 21, 555–565 (2009).
  • Krupka, I., Knauer, J., Lorentzen, L., O'Connor, T. P., Saucier, J. & Straubinger, R. K. Borrelia burgdorferi sensu lato species in Europe induce diverse immune responses against C6 peptides in infected mice. Clin Vaccine Immunol 16, 1546–1562 (2009).
  • Stenzel, W., Müller, U., Köhler, G., Heppner, F. L., Blessing, M., McKenzie, A. N. J., Brombacher, F. & Alber, G. IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis. Am J Pathol 174, 486–496 (2009).
  • Siegemund, S., Hartl, A., Buttlar, H. von, Dautel, F., Raue, R., Freudenberg, M. A., Fejer, G., Büttner, M., Köhler, G., Kirschning, C. J., Sparwasser, T. & Alber, G. Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. J Virol 83, 9411–9422 (2009).
  • Siegemund, S. & Alber, G. Cryptococcus neoformans activates bone marrow-derived conventional dendritic cells rather than plasmacytoid dendritic cells and down-regulates macrophages. FEMS Immunol Med Microbiol 52, 417–427 (2008).
  • Schulz, S. M., Köhler, G., Holscher, C., Iwakura, Y. & Alber, G. IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance. Int Immunol 20, 1129–1138 (2008).
  • Müller, U., Vogel, P., Alber, G. & Schaub, G. A. The innate immune system of mammals and insects. Contrib Microbiol 15, 21–44 (2008).
  • Schulz, S. M., Köhler, G., Schütze, N., Knauer, J., Straubinger, R. K., Chackerian, A. A., Witte, E., Wolk, K., Sabat, R., Iwakura, Y., Holscher, C., Müller, U., Kastelein, R. A. & Alber, G. Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J Immunol 181, 7891–7901 (2008).
  • Müller, U., Stenzel, W., Köhler, G., Polte, T., Blessing, M., Mann, A., Piehler, D., Brombacher, F. & Alber, G. A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. J Infect Dis 198, 1714–1721 (2008).
  • Töpfer, K. H. & Straubinger, R. K. Characterization of the humoral immune response in dogs after vaccination against the Lyme borreliosis agent A study with five commercial vaccines using two different vaccination schedules. Vaccine 25, 314–326 (2007).
  • Müller, U., Stenzel, W., Köhler, G., Werner, C., Polte, T., Hansen, G., Schütze, N., Straubinger, R. K., Blessing, M., McKenzie, A. N. J., Brombacher, F. & Alber, G. IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J Immunol 179, 5367–5377 (2007).
  • Knauer, J., Siegemund, S., Müller, U., Al-Robaiy, S., Kastelein, R. A., Alber, G. & Straubinger, R. K. Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells. FEMS Immunol Med Microbiol 49, 353–363 (2007).
  • Siegemund, S., Schütze, N., Freudenberg, M. A., Lutz, M. B., Straubinger, R. K. & Alber, G. Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis. Immunobiology 212, 739–750 (2007).
  • Alber, G., Al-Robaiy, S., Kleinschek, M., Knauer, J., Krumbholz, P., Richter, J., Schoeneberger, S., Schuetze, N., Schulz, S., Toepfer, K., Voigtlaender, R., Lehmann, J. & Mueller, U. Induction of immunity and inflammation by interleukin-12 family members. Ernst Schering Res Found Workshop, 107–127 (2006).
  • Kleinschek, M. A., Muller, U., Brodie, S. J., Stenzel, W., Kohler, G., Blumenschein, W. M., Straubinger, R. K., McClanahan, T., Kastelein, R. A. & Alber, G. IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J Immunol 176, 1098–1106 (2006).
  • Lehmann, J., Springer, S., Werner, C. E., Lindner, T., Bellmann, S., Straubinger, R. K., Selbitz, H.-J. & Alber, G. Immunity induced with a Salmonella enterica serovar Enteritidis live vaccine is regulated by Th1-cell-dependent cellular and humoral effector mechanisms in susceptible BALB/c mice. Vaccine 24, 4779–4793 (2006).
  • Al-Robaiy, S., Knauer, J. & Straubinger, R. K. Borrelia burgdorferi organisms lacking plasmids 25 and 28-1 are internalized by human blood phagocytes at a rate identical to that of the wild-type strain. Infect Immun 73, 5547–5553 (2005).
  • Schuetze, N., Schoeneberger, S., Mueller, U., Freudenberg, M. A., Alber, G. & Straubinger, R. K. IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages. Int Immunol 17, 649–659 (2005).
  • Müller, U., Sobek, V., Balkow, S., Hölscher, C., Müllbacher, A., Museteanu, C., Mossmann, H. & Simon, M. M. Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway. Eur J Immunol 33, 70–78 (2003).
  • Lehmann, J., Bellmann, S., Werner, C., Schröder, R., Schütze, N. & Alber, G. IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J Immunol 167, 5304–5315 (2001).
  • Straubinger, R. K., Dharma Rao, T., Davidson, E., Summers, B. A., Jacobson, R. H. & Frey, A. B. Protection against tick-transmitted Lyme disease in dogs vaccinated with a multiantigenic vaccine. Vaccine 20, 181–193 (2001).
  • Decken, K., Köhler, G., Palmer-Lehmann, K., Wunderlin, A., Mattner, F., Magram, J., Gately, M. K. & Alber, G. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun 66, 4994–5000 (1998).
  • Lehmann, J. & Alber, G. Murine leishmaniosis: a paradigm for the importance of T helper 1 and T helper 2 cells. Rev - Off Int Epizoot 17, 176–187 (1998).

This could also be of interest to you

Research on the subject of cryptococcosis

Read more

Research on the immune system of pigs

Read more

Research around the topic T-cells of the dog

Read more

Doctorates, Habilitations and more

Read more

Devices of the Institute

Read more
Back to top