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For some years now, the Institute of Immunology has been intensively investigating the importance of CD4/CD8 double-positive T cells in dogs. New findings have now led to a publication in the journal PLOS One. The publication went online on March 13, 2019.

The proportion of CD4/CD8 double-positive T-cells in dogs differs depending on the organ studied. Here as an example blood and small intestine. Graphic: Friederike Rabiger

The description of CD4, CD8-double-positive T cells in dogs is still relatively new. The institute has set itself the task of characterising the double-positive cell populations and deciphering their function. Veterinarian Mrs. Rabiger, led by Dr. Eschke, found important facts in her doctoral thesis which have now been published.

 

Canine tissue-associated CD4+CD8α+ double-positive T cells are an activated T cell subpopulation with heterogeneous functional potential.
Rabiger FV, Bismarck D, Protschka M, Köhler G, Moore PF, Büttner M, von Buttlar H, Alber G, Eschke M.
PLoS One. 2019 Mar 13;14(3):e0213597. doi: 10.1371/journal.pone.0213597 . eCollection 2019.

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